Data center has become the core carrier of modern information construction, but the lightning protection and grounding system of data center, as an important part of ensuring data security, has not attracted enough attention. This paper discusses the technical points of lightning protection and grounding system, such as data center location, data center lightning protection and grounding system, direct lightning protection, induction lightning protection and lightning counterattack prevention, hoping that through these discussions the data center can be more efficient, safe and reliable.