Combined with the logistics system design of a large general hospital project, this paper analyzes and summarizes the hospital logistics system from the aspects of planning layout, streamline organization, equipment selection, technical points and so on. It will transform the traditional logistics mode to the automatic digital information management mode, reasonably plan the building space, and build a safe and efficient logistics transmission system. Taking Nanning Wuxiang New Area Cancer Hospital as an example, this paper introduces the key technical points of the compound logistics system designed according to the scale and actual demand of the hospital.