The efficiency of traditional building power supply and distribution system is low and can not meet the power supply demand of some intelligent buildings. Therefore, the design and research of intelligent building power supply and distribution system based on intelligent perception is proposed. In the hardware part of the method, transformer, power distribution main line, lightning protection earthing device and SPD surge protector are designed. In the software part, the power supply and distribution knowledge base of intelligent building is constructed first, and then the power supply and distribution model of intelligent building is designed based on intelligent perception to realize the power supply and distribution of intelligent building. The results show that the designed power supply and distribution system of intelligent building has good distribution performance and has certain application value, which can be used as a reference for subsequent intelligent building power distribution.