Smart medical buildings is an important development direction of medical architecture, which can significantly improve the scientific and technological content of medical services. It also plays an important role in ensuring the quality of medical care and improving the relationship between doctors and patients. Through the construction of Huoshenshan Hospital, the paper analyzes the design of smart medical architecture in the context of the COVID-19 pandemic. On the basis of defining the design objectives of smart medical architecture, it emphasizes the combination and application of design ideas and typical systems. It aims to play a positive role in the process of smart medical architecture design, so as to promote the reform and upgrade of the modern medical system and solve the difficult medical problems that most people concerned.